Police and the FBI have been looking for similarities between three missing persons cases in Chillicothe and two in Columbus.
And as they compare notes and look for similarities in these cases, they are looking beyond Ross County and in Scioto County.
It's been more than two years since Megan Lancaster’s family has seen her.
"April the third of ’13,” Megan’s sister Kadie Lancaster said. “So yeah, twenty-six months."
She admits hope of seeing her sister in law again is fading.
"You look at the little boy, and you can't help but keep fighting,” she said.
Megan's 9-year-old son is just one of the people wondering what happened to her.
Megan was 25 years old when her family last heard from her. Her car was found in the parking lot of a Portsmouth Rally's.
"She would not have left on her own,” Kadie said.
Kadie said Megan had slipped into a life of drugs, addiction, and prostitution.
"It broke my heart to see her go down that road, because I knew what she could be. I knew how she could change her life. God bless her, she just couldn't beat it," she said.
Addiction is something Megan had in common with three Ross County women who've disappeared in the last year: Charlotte Trego, Wanda Lemons, and Tiffany Sayre.
Investigators aren't saying there is a connection, but say some of the women have places and people in common.
"They're not disposable,” Kadie said. “They are human beings."
Kadie believes there is a connection between the disappearances and deaths and she said Megan's family won't stop until they have answers.
"We've had other family members scream at us, ‘She's gone. She's dead. Get over it. Go on.’ And we can't. We have to know what happened to her. We want to put a rest to this. Not just her- to all of these missing women," she said.
Portsmouth police did not return 10TV’s calls for information on Megan Lancaster's case but Chillicothe Police said they want to hear from anyone with information on any of these cases.