A ramp on the west side of Columbus is expected to be closed until at least 8 p.m. on Monday.
A semi crashed onto its side around 3 p.m. on the ramp from I-70 Eastbound to I-270 Northbound.
The truck was carrying produce.
The Ohio Department of Transportation says the truck is leaking diesel fuel.
Police said they expected the ramp to be closed four to six hours.
Motorists should expect delays in the area and plan to take an alternative route.