President Barack Obama says he's nominating his budget director, Sylvia Mathews Burwell, to succeed Kathleen Sebelius as Health and Human Services secretary.
The Cabinet shuffle lets Obama put a new face on his new health care law.
The move comes more than a week after the close of sign-ups for insurance coverage on the law.
After a rocky start that Sebelius was blamed for, the administration rebounded strongly to exceed expectations by enrolling 7.1 million people by the March 31 deadline.
Burwell's nomination requires Senate confirmation.