US 23 was shut down near Blackwater Road in Ross County Saturday after a driver over corrected, causing her vehicle to overturn.
The Chillicothe Post of the Ohio State Highway Patrol is currently investigating the accident.
Angela Collins, 47, Columbus was driving. She was flown to Ohio State University Wexner Medical Center for treatment.
Her passenger, John Dawson, 19, Columbus, was transported to Adena Regional Medical Center.
Their conditions are not yet available.
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