Doran Grant picked off Purdue's first pass, returning it for a touchdown, and Braxton Miller threw for 233 yards and four touchdowns Saturday as No. 4 Ohio State extended the nation's longest winning streak to 21 with a 56-0 rout at Purdue.
The Buckeyes (9-0, 5-0 Big Ten) have not lost in 22 months. Coach Urban Meyer also won his 22nd straight game, tying a personal best established at Florida.
Ohio State scored the most points and produced the most lopsided scoring margin in the 56-game history of this series. Both topped the marks set in Ohio State's 49-0 victory in 2010.
Purdue (1-7, 0-4) lost its sixth in a row.
Gray's interception helped the Buckeyes take a 28-0 lead after one quarter, and they extended it to 42-0 at the half.
Miller finished19 of 23. Kenny Guiton threw for one TD and ran for two more.