The Ohio State Highway Patrol was investigating a crash in Pike County Saturday.
The crash happened around 9:15 a.m. On Buchanan Road.
OSHP said 18-year-old Alexander Mcdowell was struck head-on by a vehicle being driven by 33-year-old Jeremy Mallow.
25-year-old Joshua Taylor, 15-year-old Christopher Chaney and 15-year-old Clayton Ison were all passengers in Mcdowell's vehicle.
Mallow was flown by Medflight to Cable-Huntington Hospital in Huntington, West Virginia and Taylor was flown by AirEvac to The Ohio State University Wexner Hospital.
Stay with 10TV and refresh 10TV.com for updates on this story.