Todd Doss, 47, left his south Columbus home on his motorcycle Sunday on the way to the store.
Just minutes later, he was struck less than a mile from his house.
On Monday, Doss remained in serious condition at Grant Medical Center after doctors were forced to amputate his leg.
His nephew found out six hours after the crash that his uncle was in the ICU, unconscious and fighting for his life.
"It was just that feeling of dread - I knew at that point that it was him,” said Andy Doss.
Police said Todd Doss was struck on Parsons Avenue near Chatterly Lane about 2 p.m. on Sunday.
According to authorities, a Buick Regal going northbound went left of center for an unknown reason.
The family says doctors were forced to amputate Todd’s leg just above his knee.
"It's going to be rough for a long time, because it's not going to go over well when he regains consciousness,” said Andy.
The police report said a female was driving the car that struck Doss, and the report indicates she ran from the scene.
"It's not fair. It wasn't his fault. It's nothing he did,” said Andy. “In the words of my dad, a woman got out of the car and ran away, but my uncle will probably never walk again. If that person is watching right now, I hope their conscious is just eating them alive to know that they almost killed a man."
Detectives believe they know who the woman is that fled the scene.
WBNS-10TV also visited the home where the vehicle is registered to, and a woman there told us her male cousin was driving the car.
Police said there are no charges at this point, and they are investigating if alcohol or drugs played a part in the crash.
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November 11, 2012 - Motorcyclist Has Leg Amputated At Scene Of Crash