Authorities responded to a semi rollover near I-71 and I-670 just before noon on Sunday.
Columbus police said the crash happened on I-670 westbound at mile marker 4, west of I-71.
The truck was reportedly carrying cylinders of pressurized natural gas. Those cylinders appeared to be secure, according to emergency officials.
The cleanup following the crash caused delays in the area around I-71, I-670 and nearby exits.
The cause of the crash was being investigated Sunday evening. The condition of the driver was not released.
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