Witnesses said Sudanese police opened fire on protesters trying to climb the walls of the U.S. Embassy in Khartoum on Friday.
The witnesses said several thousands of Sudanese were protesting outside the embassy, trying to storm it in anger over an obscure file produced in the United States that denigrated the Prophet Muhammad.
It was not immediately clear if any protesters got into the embassy.
The witnesses said at least three protesters were hurt, seen motionless on the ground. There was no immediate confirmation whether they were dead.
The attack came as protests against the film spread around the Middle East and other Muslim countries, from Tunisia to Pakistan.
A large cloud of black smoke could be seen rising around the U.S. embassy in Tunis where stone-throwing protesters and police are waging a pitched battle.
Thousands of demonstrators have massed outside the embassy and several were seen climbing the outer wall of the embassy grounds and raising a flag on which was written the Muslim profession of faith, an Associated Press reporter on the scene says.
Police responded by firing tear gas, and police gunfire could be heard.
Security officials in Lebanon said a crowd set fire to a KFC and an Arby's restaurant, and then clashed with police who opened fire, killing one person.
Security forces in Yemen fired tear gas at a crowd of about 2,000 people trying to march to the U.S. embassy.
And hundreds of Afghans protested in Jalalabad, including some who urged an end to relations with the United States.
Thousands of angry Kashmiri Muslims in India have burned U.S. flags today and called President Barack Obama a "terrorist." In a southern Indian city, protesters threw stones at the U.S. consulate, and burned Obama in effigy.
In Bangladesh, about 5,000 hardline Muslims marched through the streets of the capital after Friday prayers, burning U.S. and Israeli flags and calling for the arrest and the death of the maker of the anti-Muslim film.
A U.S. official says an elite Marine rapid response team has arrived in Yemen in the wake of violence and protests in the capital of Sanaa.
The deployment comes as Yemeni security forces were firing live rounds and tear gas into the crowd of about 2,000 protesters trying to march to the U.S. embassy. On Thursday hundreds of protesters stormed the embassy compound and burned the American flag.
The Marine unit, known as a Fleet Antiterrorism Security Team, was sent in response to Thursday's violence and as a precautionary measure, as waves of attacks roiled the Muslim world over an anti-Islam video.
The official spoke on condition of anonymity because the deployment was not made public.
A similar team was dispatched to Libya Wednesday in response to violence there.
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