Mia and Rozonno McGhee and their six children were featured on Monday's show, 10TV's AJ Smith reported.
The McGhee sextuplets were the first to be born in Columbus.
McGhee welcomed their six children in June. The babies were born at The Ohio State University Medical Center.
The family flew to Chicago earlier this month to tape the show and said organization was key to traveling with six infants.
Oprah made a plea to central Ohioans to use the family's carpet cleaning service.
"She was really down to earth, she really welcomed us and made us feel comfortable," Rozonno McGhee said. "She was like another family member."
The family had a watch party on Monday and kept some parts of the show a secret so friends and family would be surprised.
Oprah gave the couple a honeymoon and a $250,000 gift card to Walmart.
Although the children are too young to remember, their parents said it was an experience they will never forget.
"Amazing, simply amazing," Mia McGhee said. "It was like a dream."
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November 1, 2010:
Columbus Sextuplets Thriving In New Home
September 17, 2010: Last Of Sextuplets Leaves Hospital
August 11, 2010: First Of Columbus Sextuplets Goes Home
August 6, 2010: Columbus' First Set Of Sextuplets Prepare To Go Home
June 9, 2010: First Set Of Sextuplets Born At OSU Medical Center