It's been four years since Brian Shaffer was last seen going up an escalator to a bar near the Ohio State campus, but his brother expressed hope Wednesday that the case would eventually be resolved.
"If I don't see him again, that's OK," said Derek Shaffer. "But just to hear from him (and know) everything's OK; it just makes me sick to my stomach to this day that someone could have possibly hurt him, or beat him like that."
Investigators are still not sure what happened to Brian Shaffer, who was last seen on April 1, 2006.
SLIDESHOW: Search For Brian Shaffer
Surveillance cameras recorded him going up the escalator to the Ugly Tuna Saloona bar, located in the South Campus Gateway, but the Ohio State medical student was never seen again.
Shaffer, a second-year medical student at Ohio State, went to the bar to celebrate the beginning of spring break with several of his friends when he disappeared.
Columbus police detectives have traveled to six states and the U.S. Virgin Islands to follow up on potential leads in the case.
Central Ohio Crime Stoppers continues to ask for tips in Shaffer's disappearance. It is offering a reward of up to $25,000 for information on his whereabouts.
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